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31.
Toshio Ogawa Masakazu Sakai Wataru Ishitobi 《Journal of polymer science. Part A, Polymer chemistry》1986,24(1):109-118
Molecular weight distribution of Nylon 12 was determined with hexafluoroisopropanol/toluene mixture as eluent by gel permeation chromatography. Calibration curve for Nylon 12 was easily obtained from that of polystyrene because the method of universal calibration was applicable among these polymers. The molecular weight distributions of Nylon 12 were always broader than expected by the theory of polymerization, i.e., most probable distribution. This result was not caused by broadening effect in gel permeation chromatography, but by polymerization itself. 相似文献
32.
M Ogawa H Matsuda H Eto T Asaoka T Kuraishi A Iwasa T Nakashima K Yamaguchi 《Chemical & pharmaceutical bulletin》1991,39(9):2301-2307
A series of vinylimidazoles containing a hetero atom such as sulfur or oxygen at a beta-position of the vinyl group was prepared and the antifungal activities were tested. It was found that sulfur-substituted derivatives such as (E)-1-[2-(methylthio)-1-[2-(pentyloxy)phenyl]ethenyl]-1H-imidazole (5a-5) and (E)-1-[1-[2-(hexyloxy)phenyl]-2-(methylthio)ethenyl]-1H-imidazole (5a-6) showed excellent antifungal activities against dermatophytes and yeast cells. The stereochemistry of the hydrochloride salt of 5a-5 was determined by X-ray crystallography. The structure-activity relationships were discussed. 相似文献
33.
Photooxygenations of 4-2H-anisole () and o-xylene () by 3-methylpyridazine 2-oxide () or pyridine 1-oxide () were studied in a variety of solvents at varying irradiation temperatures. Remarkable solvent effect on NIH-shift coupled with their hydroxylation processes was observed. 相似文献
34.
Abe A Saito Y Imaizumi M Ogawa M Takeichi T Jinno K 《Journal of separation science》2005,28(17):2413-2418
The surface derivatization of poly(p-phenylene terephthalamide) fiber was studied. The obtained surface-derivatized filaments were packed into a fused-silica capillary to evaluate its surface characteristics by using GC. As the stationary phase for GC the surface-derivatized fibers showed higher retention for alkanes and alkylbenzenes than that with the untreated Kevlar fiber. The improvements on the retention power and the peak shape were observed on the benzyl-modified fibrous stationary phase. The derivatized fibrous materials were also evaluated as the extraction medium in fiber-in-tube SPE, and the effect of the surface modification on the extraction power was compared to the parent fiber. The results indicated that the modified fiber possessed a higher extraction power than the untreated fiber. Based on the facts, the successful modification of the fiber surface was estimated. 相似文献
35.
Kawasaki T Nonaka Y Watanabe K Ogawa A Higuchi K Terashima R Masuda K Sakamoto M 《The Journal of organic chemistry》2001,66(4):1200-1204
The reverse aromatic Cope rearrangement of 2-allyl-3-alkylideneindolines obtained by Horner-Wadsworth-Emmons olefination of 2-allylindolin-3-ones was performed. When 2-allylindolin-3-ones were treated with phosphonium ylides in refluxing toluene, domino Wittig reaction and reverse aromatic Cope rearrangement took place to give alpha-allyl-3-indole acetate derivatives in good yields. The aromatization as a new driving force in the Cope rearrangement is preferable to the conjugation with the carbonyl and cyano groups and also to the alkyl substitution pattern, which are well-known driving forces. 相似文献
36.
Sano S Takehisa T Ogawa S Yokoyama K Nagao Y 《Chemical & pharmaceutical bulletin》2002,50(9):1300-1302
Tetrasubstituted (Z)-alkenes were readily prepared through the Horner-Wadsworth-Emmons reactions of methyl 2-[bis(2,2,2-trifluoroethyl)phosphono]propionate with aryl alkyl ketones by employing Sn(OSO(2)CF(3))(2) and N-ethylpiperidine. 相似文献
37.
Tomomi KawasakiAtsuyo Ogawa Yasuyuki TakashimaMasanori Sakamoto 《Tetrahedron letters》2003,44(8):1591-1593
A new and efficient total synthesis of (−)-pseudophrynaminol, the pyrrolo[2,3-b]indole alkaloid bearing the allylic moiety at the 3a-position, has been achieved by a sequence involving 3-allylindol-2-one 8 as a key intermediate. The enantioselective construction of the quaternary carbon in 8 was performed through a tandem cascade reaction of 2-allyloxyindolin-3-one 4, olefination, isomerization, and asymmetric Claisen rearrangement. 相似文献
38.
The degradation of acenaphthylene, acenaphthene, 2-methylnaphthalene, 2-methylindene, 3-methylindene and indene in water solutions was studied. These compounds at the 25-150 mug/l. level were almost totally degraded at ambient temperature within three days. The microbial population responsible for the degradation occurs naturally in ground-water taken from an aquifer in Ames, Iowa, which is contaminated with coal-tar products. These unidentified micro-organisms adapt readily to other waters when used as an inoculant for the degradation of aromatic compounds. The preservation of water to prevent such degradation was also investigated. Filtration through a 0.45-mum filter was found the most effective procedure for preserving the hydrocarbons in these waters. 相似文献
39.
Ogawa T Araki M Miyamae T Okayama T Hagiwara M Sakurada S Morikawa T 《Chemical & pharmaceutical bulletin》2003,51(7):759-771
To improve the oral bioavailability of a dermorphin tetrapeptide analog, N(alpha)-1-iminoethyl-Tyr-D-MetO-Phe-MebetaAla-OH (III), which has a potent analgesic activity after oral administration, various derivatives were synthesized to increase lipophilicity by esterification of the C-terminal carboxyl group and/or acylation of the phenolic hydroxyl group on Tyr1. Antinociceptive activity was evaluated after subcutaneous or oral administration using the mouse tail pressure test. As a result, increased antinociceptive activity after oral administration as well as an improved ED50(p.o.)/ED50(s.c.) ratio, which is an indicator of oral bioavailability, were found for some compounds. With regard to the improvement of bioavailability, derivatives with acylation of the phenolic hydroxyl group on Tyr1 showed better results than derivatives with esterification of the C-terminal carboxyl group. In particular, an ED50(p.o.)/ED50(s.c.) ratio equivalent to that of morphine was found for an acetylated derivative, N(alpha)-1-iminoethyl-Tyr(COMe)-D-MetO-Phe-MebetaAla-OH (7a), as well as for a methoxycarbonylated derivative, N(alpha)-1-iminoethyl-Tyr(CO2Me)-D-MetO-Phe-MebetaAla-OH (7l). 相似文献
40.
Jun-ichi KawakamiMitsuhiro Takeba Ikuyo KamiyaNoboru Sonoda Akiya Ogawa 《Tetrahedron》2003,59(34):6559-6567
Highly regioselective thioformylation of terminal acetylenes with thiols and carbon monoxide has been developed by the use of rhodium(I) complexes as the catalyst: formyl and thio groups are introduced into the terminal and inner positions of acetylenes, respectively. The thioformylation is performed in the presence of a catalytic amount of rhodium(I) complexes, such as RhH(CO)(PPh3)3, RhCl(PPh3)3, and RhCl(CO)(PPh3)2, under the pressure of CO (3 MPa) at 120°C in CH3CN to provide β-thio-α,β-unsaturated aldehydes in good yields. This thioformylation can be applied to a variety of terminal acetylenes and aromatic thiols. A mechanistic proposal includes the formation of the rhodium sulfide complex as the key species. 相似文献